反应详情

Ethanol (40 ml) and a 10% aqueous solution (20 ml) of sodium hydroxide were added to 1.32 g (3.3 mmol) of 2-cyclopropyl-3-(2'-methoxycarbonylbiphenyl-4-yl)methyl-7-methyl-3H-imidazo[4,5-b]pyridine, followed by heating under reflux for 2 hours. After the reaction liquid was cooled, it was concentrated to about one-half the initial volume, and neutralized with 2N hydrochloric acid and acetic acid. The crystal thus precipitated was recovered by filtration and recrystallized from aqueous ethanol to give 1.03 g of the title compound (yield 81%).

1. temperatureby heating
2. temperatureunder reflux for 2 hours
3. customAfter the reaction liquid
4. temperaturewas cooled
5. concentrationit was concentrated to about one-half the initial volume
6. customThe crystal thus precipitated
7. filtrationwas recovered by filtration
8. customrecrystallized from aqueous ethanol