HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Benzyl-8-methoxy-1,2,3,3a,8,8a-hexahydroindeno[1,2-c]pyrrole hydrochloride → 8-Methoxy-1,2,3,3a,8,8a-hexahydro-indeno[1,2-c]pyrrole hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Benzyl-8-methoxy-1,2,3,3a,8,8a-hexahydroindeno[1,2-c]pyrrole hydrochloride | HCID 19795702 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 8-Methoxy-1,2,3,3a,8,8a-hexahydro-indeno[1,2-c]pyrrole hydrochloride | HCID 67855986 | 90.5% |
Reaction Steps
The product from Example 5 (4.90 g) was hydrogenated with 2.45 g 20% Pd/C in 200 ml methanol at 3 atm, affording 3.17 g of the desired product, mp: 208°-209° C. NMR (d6DMSO/D2O) δ2.83 (m, 2H), 3.14-3.29 (m, 3H), 3.46 (dd, 1H), 3.55 (dd, 1H), 3.80 (s, 3H), 3.95 (m, 1H), 6.85 (d, 2H), 7.25 (t, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05244888 |
| Source dataset | uspto-grants-1993_09 |
| ORD ID | ord-7fb126bc875649eb8713b2431fdb30fa |
| Source note | uspto-grants-1993_09 |