反应详情

2-Fluoro-3-nitrobenzoic acid methyl ester (9.10 g, 0.046 mol), 10% hydrochloric acid/methanol (25 ml), methanol (60 ml), and 5% palladium/carbon (50% wet product) (2.7 g) were introduced, and the reaction mixture was hydrogenated at room temperature. After completion of the reaction, the catalyst was filtered away, and the filtrate was concentrated under reduced pressure. The concentration residue was washed with diisopropyl ether, as a result of which 8.01 g (yield: 85%) of the indicated compound was obtained.

1. customwas hydrogenated at room temperature
2. customAfter completion of the reaction
3. filtrationthe catalyst was filtered away
4. concentrationthe filtrate was concentrated under reduced pressure
5. washThe concentration residue was washed with diisopropyl ether