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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 534721Generated: October 28, 2026

Potassium Hydroxide → 1,1-Dimethylethyl (2R)-4-[(4-aminophenyl)methyl]-2-methyl-1-piperazinecarboxylate

https://huagongshe.com/reaction/534721

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium HydroxideHCID 14797—
Reactant1,1-Dimethylethyl (2R)-2-methyl-4-[(4-nitrophenyl)methyl]-1-piperazinecarboxylateHCID 59262157—
Reactant1,1-Dimethylethyl (2S)-4-[(4-aminophenyl)methyl]-2-methyl-1-piperazinecarboxylateHCID 59262217—
Product1,1-Dimethylethyl (2R)-4-[(4-aminophenyl)methyl]-2-methyl-1-piperazinecarboxylateHCID 59262164—

Reaction Steps

The title compound was prepared from 1,1-dimethylethyl (2R)-2-methyl-4-[(4-nitrophenyl)methyl]-1-piperazinecarboxylate (D4) using a method similar to that described for D2 in Description 2 although aq. 2M KOH solution was used in place of solid KOH and the reaction time was 40 minutes. MS (ES): MH+ 306.2, MNa+ 328.2.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08853218B2
Source datasetuspto-grants-2014_10
ORD IDord-df60df0cb3a44d13be69058840c0f323
Source noteuspto-grants-2014_10