HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 534726Generated: October 26, 2026
Sodium borohydride → 1-Boc-4-(4-Methylaminobenzyl)piperazine
https://huagongshe.com/reaction/534726
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 1,1-Dimethylethyl (2S)-2-methyl-4-{[4-(methylamino)phenyl]methyl}-1-piperazinecarboxylate | HCID 59262131 | — |
| Product | 1-Boc-4-(4-Methylaminobenzyl)piperazine | HCID 46835451 | — |
Reaction Steps
The title compound was prepared from D11 using a method similar to that described for D3 in Description 3A although the reaction was heated at 50° C. overnight prior to addition of sodium borohydride and no column chromatography was required. δH (CDCl3, 400 MHz) 7.11 (2H, d), 6.57 (2H, d), 3.69 (1H, br.s), 3.40 (6H, m), 2.83 (3H, s), 2.36 (4H, m), 1.45 (9H, s) [δ values corrected for incorrectly referenced TMS at 0.58 ppm on spectrum]. MS (ES+): 206.2, no molecular ion (MH+) observed.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08853218B2 |
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| Source dataset | uspto-grants-2014_10 |
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| ORD ID | ord-4dca912e0f4b400cad2b05172d6e14e0 |
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| Source note | uspto-grants-2014_10 |
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