HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluorophenol → 1,1-Dimethylethyl (2S)-4-({4-[({6-[(3-fluorophenyl)oxy]-3-pyridinyl}carbonyl)(methyl)amino]phenyl}methyl)-2-methyl-1-piperazinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluorophenol | HCID 9743 | — |
| Reactant | 1,1-Dimethylethyl (2S)-4-({4-[[(6-chloro-3-pyridinyl)carbonyl](methyl)amino]phenyl}methyl)-2-methyl-1-piperazinecarboxylate | HCID 59262229 | — |
| Product | 1,1-Dimethylethyl (2S)-4-({4-[({6-[(3-fluorophenyl)oxy]-3-pyridinyl}carbonyl)(methyl)amino]phenyl}methyl)-2-methyl-1-piperazinecarboxylate | HCID 59262148 | — |
Reaction Steps
The title compound was prepared from 1,1-dimethylethyl (2S)-4-({4-[[(6-chloro-3-pyridinyl)carbonyl](methyl)amino]phenyl}methyl)-2-methyl-1-piperazinecarboxylate (D54) and 3-fluorophenol in a similar manner to that described for D55 in Description 55, yielding the title compound as a pale yellow oil (0.057 g). MS (ES): MH+ 535.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08853218B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-2b79d385df324af8a108d30c9e35a633 |
| Source note | uspto-grants-2014_10 |