Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thionyl Chloride → 6-(3-Fluorophenyl)-3-pyridinecarbonyl chloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 6-(3-Fluorophenyl)nicotinic acid | HCID 24729972 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 6-(3-Fluorophenyl)-3-pyridinecarbonyl chloride | HCID 86618110 | 99.3% |
반응 단계
6-(3-Fluorophenyl)-3-pyridinecarboxylic acid (82 mg, 0.376 mmol) was stirred in dioxane (4 mL) and thionyl chloride (0.137 mL, 1.88 mmol) added dropwise. The reaction mixture was heated at reflux for 40 min then concentrated in vacuo to give 6-(3-fluorophenyl)-3-pyridinecarbonyl chloride as a white solid (0.088 g) which was used directly in step 2.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08853218B2 |
| 출처 데이터셋 | uspto-grants-2014_10 |
| ORD ID | ord-c4505d7185bb43ecbb62bf048c82df5f |
| 출처 메모 | uspto-grants-2014_10 |