HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 534753Generated: October 25, 2026
Oxalyl chloride → 5-Bromo-pyridine-2-carbonyl chloride
https://huagongshe.com/reaction/534753
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 5-Bromopyridine-2-carboxylic acid | HCID 608544 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-Bromo-pyridine-2-carbonyl chloride | HCID 19090771 | — |
Reaction Steps
The acid from step 1 (0.702 g, 3.475 mmol) was suspended in DCM (40 mL) under argon, DMF (1 drop) was added and the mixture was cooled in an ice-bath. Oxalyl chloride was added portion-wise over 5 minutes and the mixture was then heated to 40° C. for 90 minutes. On cooling, the solvent was removed to produce 5-bromo-2-pyridinecarbonyl chloride (0.801 g) as a brown solid which was used in step 3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08853218B2 |
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| Source dataset | uspto-grants-2014_10 |
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| ORD ID | ord-a23c7d8561344844955800d53c2c43f4 |
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| Source note | uspto-grants-2014_10 |
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