HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluorophenol → 1,1-Dimethylethyl (2S)-4-({4-[({5-[(3-fluorophenyl)oxy]-2-pyridinyl}carbonyl)(methyl)amino]phenyl}methyl)-2-methyl-1-piperazinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluorophenol | HCID 9743 | — |
| Reactant | 4,8,12,16-Tetramethylheptadecanoic acid | HCID 3080668 | — |
| Reactant | 1,1-Dimethylethyl (2S)-4-({4-[[(5-bromo-2-pyridinyl)carbonyl](methyl)amino]phenyl}methyl)-2-methyl-1-piperazinecarboxylate | HCID 59262238 | — |
| Catalyst | Cuprous chloride | HCID 62652 | — |
| Product | 1,1-Dimethylethyl (2S)-4-({4-[({5-[(3-fluorophenyl)oxy]-2-pyridinyl}carbonyl)(methyl)amino]phenyl}methyl)-2-methyl-1-piperazinecarboxylate | HCID 59262184 | — |
Reaction Steps
The title compound was prepared from 1,1-dimethylethyl (2S)-4-({4-[[(5-bromo-2-pyridinyl)carbonyl](methyl)amino]phenyl}methyl)-2-methyl-1-piperazinecarboxylate (D72) and 3-fluorophenol using a method similar to that described for D73 in Description 73 although 1 eq. CuCl and 0.25 eq. THMD were used. MS (ES): MH+ 535.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08853218B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-4236b5af72f54bf18c063032af5a22c5 |
| Source note | uspto-grants-2014_10 |