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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 534765Generated: October 29, 2026

4-Nitrobenzaldehyde → (3R,5S)-1-[(4-Nitrophenyl)methyl]-3,5-dimethylpiperazine

https://huagongshe.com/reaction/534765

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-NitrobenzaldehydeHCID 541—
Reactantrel-(2R,6S)-2,6-dimethylpiperazineHCID 6950261—
Reactant1,1-Dimethylethyl (2S)-2-methyl-4-[(4-nitrophenyl)methyl]-1-piperazinecarboxylateHCID 59262204—
Product(3R,5S)-1-[(4-Nitrophenyl)methyl]-3,5-dimethylpiperazineHCID 59262210—

Reaction Steps

The title compound was prepared from 4-nitrobenzaldehyde and (2R,6S)-2,6-dimethylpiperazine using a method similar to that described for D1 in Description 1A. MS (ES): MH+ 250.2

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08853218B2
Source datasetuspto-grants-2014_10
ORD IDord-6c9b5b1fef6b4944b1eae2f231cb6279
Source noteuspto-grants-2014_10