HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 534784Generated: October 26, 2026
Sodium borohydride → 1,1-Dimethylethyl (2S)-4-{[2-chloro-4-(methylamino)phenyl]methyl}-2-methyl-1-piperazinecarboxylate
https://huagongshe.com/reaction/534784
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 1,1-Dimethylethyl (2S)-2-methyl-4-{[4-(methylamino)phenyl]methyl}-1-piperazinecarboxylate | HCID 59262131 | — |
| Reactant | 1,1-Dimethylethyl (2S)-4-[(4-amino-2-chlorophenyl)methyl]-2-methyl-1-piperazinecarboxylate | HCID 59262132 | — |
| Product | 1,1-Dimethylethyl (2S)-4-{[2-chloro-4-(methylamino)phenyl]methyl}-2-methyl-1-piperazinecarboxylate | HCID 59262120 | — |
Reaction Steps
The title compound was prepared from 1,1-dimethylethyl (2S)-4-[(4-amino-2-chlorophenyl)methyl]-2-methyl-1-piperazinecarboxylate (D104) using a method similar to that described for D3 in Description 3A although the reaction was heated at 50° C. overnight prior to, and for 24 h after addition of sodium borohydride. (3 eq.). MS (ES): MH+ 354/356.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08853218B2 |
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| Source dataset | uspto-grants-2014_10 |
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| ORD ID | ord-8857693096e543e4a804a3d454a87f03 |
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| Source note | uspto-grants-2014_10 |
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