Dimethylformamide → HCID 24902687, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of tert-butyl 4-({[(4-methylphenyl)sulfonyl]oxy}methyl)piperidine-1-carboxylate obtained in Reference Example 4 (8.0 g), methyl 4-hydroxybenzoate (3.1 g), potassium carbonate (5.53 g), and N,N-dimethylformamide (80 mL) was stirred at 60° C. for 16 h. Water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to provide the title compound (7.12 g, 100%) as crystals.

Provenance & Evidence