3-Chloro-5-(trifluoromethyl)benzaldehyde → 1-[3-chloro-5-(trifluoromethyl)phenyl]ethanone

HRID 534842Notes

Reaction equation

HRID 534842 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:12]([OH:14])[CH3:13])[CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.ClC1C=C(C=C(C(F)(F)F)C=1)C=O>>[Cl:1][C:2]1[CH:3]=[C:4]([C:12](=[O:14])[CH3:13])[CH:5]=[C:6]([C:8]([F:10])([F:11])[F:9])[CH:7]=1

Participants

3

Reactant 2

HCID 38570333-Chloro-5-(trifluoromethyl)benzaldehydeHCID 667510011-(3-Chloro-5-(trifluoromethyl)phenyl)ethanol

Product 1

HCID 38590621-[3-chloro-5-(trifluoromethyl)phenyl]ethanoneYield 86%

Procedure

The title compound was prepared from 1-(3-chloro-5-(trifluoromethyl)phenyl)ethanol (Reference Example 32) by a procedure similar to the one described for 3-chloro-5-(trifluoromethyl)benzaldehyde (Reference Example 31) to provide 1-(3-chloro-5-(trifluoromethyl)phenyl)ethanone (0.998 g, 86%) as a pale yellow oil.

Sources & evidence

ORD record
ord-8769ceaf4697486aa9a7d682796e1067
Source dataset
uspto-grants-2014_10
Patent number
US08853215B2

Reaction notes

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