3-Chloro-5-(trifluoromethyl)benzaldehyde → 3-Bromo-5-(trifluoromethyl)benzaldehyde

HRID 534846Notes

Reaction equation

HRID 534846 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH2:12][OH:13])[CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.ClC1C=C(C=C(C(F)(F)F)C=1)C=O>>[Br:1][C:2]1[CH:3]=[C:4]([CH:5]=[C:6]([C:8]([F:9])([F:10])[F:11])[CH:7]=1)[CH:12]=[O:13]

Participants

3

Reactant 2

HCID 38570333-Chloro-5-(trifluoromethyl)benzaldehydeHCID 29919767[3-Bromo-5-(trifluoromethyl)phenyl]methanol

Product 1

HCID 161154383-Bromo-5-(trifluoromethyl)benzaldehydeYield 85%

Procedure

The title compound was prepared from (3-bromo-5-(trifluoromethyl)phenyl)methanol (Reference Example 38) by a procedure similar to the one described for 3-chloro-5-(trifluoromethyl)benzaldehyde (Reference Example 31) to provide 3-bromo-5-(trifluoromethyl)benzaldehyde (22.03 g, 85%) as a pale yellow oil.

Sources & evidence

ORD record
ord-ffc1d73a0b334b76b5e93acbeae25e3f
Source dataset
uspto-grants-2014_10
Patent number
US08853215B2

Reaction notes

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