HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 3-(4-(3-chloro-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoate → Methyl 3-(4-(3-bromo-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 3-(4-(3-chloro-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoate | HCID 66751004 | — |
| Reactant | 2-(3-Bromo-5-(trifluoromethyl)phenyl)-2-oxoethyl methyl succinate | HCID 66751127 | — |
| Product | Methyl 3-(4-(3-bromo-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoate | HCID 66750877 | 47% |
Reaction Steps
The title compound was prepared from 2-(3-bromo-5-(trifluoromethyl)phenyl)-2-oxoethyl methyl succinate (Reference Example 43) by a procedure similar to the one described for methyl 3-(4-(3-chloro-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoate (Reference Example 36) to provide methyl 3-(4-(3-bromo-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoate (3.62 g, 47%) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08853215B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-e7c04fbec89540679741e972ea316296 |
| Source note | uspto-grants-2014_10 |