Methyl 3-(4-(3-(prop-1-en-2-yl)-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoate → Methyl 3-(4-(3-isopropyl-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoate

Participants

Reaction Steps

To a nitrogen sparged solution of methyl 3-(4-(3-(prop-1-en-2-yl)-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoate (Reference Example 49, 0.200 g, 0.589 mmol) in ethanol (50.0 mL) was added 10% Pd/C (0.025 g) in a Parr bottle, and the mixture was vigorously shaken under an atmosphere of hydrogen (40 psi) at room temperature for 4 h. After this time, the reaction mixture was filtered through a pad of Celite, the filter cake was washed with ethanol and the filtrate was concentrated under reduced pressure to provide methyl 3-(4-(3-isopropyl-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoate (0.191 g, 95%) as a colorless oil.

Provenance & Evidence