Methyl 3-(4-(3-(thiophen-3-yl)-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoate → 3-(4-(3-(Thiophen-3-yl)-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoic acid

HRID 534864Notes

Reaction equation

HRID 534864 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([C:6]2[CH:7]=[C:8]([C:16]3[N:17]=[C:18]([CH2:21][CH2:22][C:23]([O:25]C)=[O:24])[O:19][CH:20]=3)[CH:9]=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:11]=2)=[CH:2]1.ClC1C=C(C2N=C(CCC(O)=O)OC=2)C=C(C(F)(F)F)C=1>>[S:1]1[CH:5]=[CH:4][C:3]([C:6]2[CH:7]=[C:8]([C:16]3[N:17]=[C:18]([CH2:21][CH2:22][C:23]([OH:25])=[O:24])[O:19][CH:20]=3)[CH:9]=[C:10]([C:12]([F:13])([F:14])[F:15])[CH:11]=2)=[CH:2]1

Participants

3

Reactant 2

HCID 66750869Methyl 3-(4-(3-(thiophen-3-yl)-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoateHCID 667511183-(4-(3-Chloro-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoic acid

Product 1

HCID 667510063-(4-(3-(Thiophen-3-yl)-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoic acidYield 77%

Procedure

The title compound was prepared from methyl 3-(4-(3-(thiophen-3-yl)-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoate (Reference Example 48) by a procedure similar to the one described for 3-(4-(3-chloro-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoic acid (Reference example 52) to provide 3-(4-(3-(thiophen-3-yl)-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoic acid (0.268 g, 77%) as a white solid.

Sources & evidence

ORD record
ord-a2f5c0c0103441078bef065f96f0e34a
Source dataset
uspto-grants-2014_10
Patent number
US08853215B2

Reaction notes

Loading…