Tetrahydrofuran → HCID 86663399, compound

Participants

Reaction Steps

A mixture of 1-(2-tert-butylphenyl)piperazine dihydrochloride obtained in Reference Example 1 (0.5 g), 6-chloropyridine-3-carbonyl chloride (352 mg), triethylamine (0.835 mL), and tetrahydrofuran (30 mL) was stirred at room temperature for over-night. Water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by flash column chromatography (NH-silica gel, 0:100 hexane/ethyl acetate) to provide the title compound (635 mg, quant.) as a solid.

Provenance & Evidence