Hydrochloric Acid → HCID 66792699, compound

Participants

Reaction Steps

A mixture of ethyl [(5-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}pyridin-2-yl)sulfanyl]acetate obtained in Example 21 (390 mg), 1 M sodium hydroxide solution (12 mL), methanol (30 mL), and tetrahydrofuran (30 mL) was stirred at room temperature for 3 h. 1 M hydrochloric acid solution was added to the reaction solution, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to provide the title compound (336 mg, 99%) as crystals.

Provenance & Evidence