Trifluoroacetic acid → HCID 178440806, compound

Participants

Reaction Steps

A mixture of tert-butyl [(5-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}-1H-benzimidazol-2-yl)sulfanyl]acetate obtained in Example 29 (763 mg) and trifluoroacetic acid (3 mL) was stirred at room temperature for 3 h. Water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to provide the title compound (475 mg, 70%) as crystals.

Provenance & Evidence