Trifluoroacetic acid → [(5-{[4-(2-tert-Butylphenyl)piperazin-1-yl]carbonyl}pyridin-3-yl)oxy]acetic acid

Participants

Reaction Steps

A mixture of tert-butyl [(5-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}pyridin-3-yl)oxy]acetate obtained in Example 35 (500 mg) and trifluoroacetic acid (7 mL) was stirred at room temperature for 3 h. Water was added to the reaction solution, and subsequently 1 M sodium hydroxide solution was added to the mixture to pH 5-6. The resulting precipitate was collected and dried under reduced pressure to provide the title compound (405 mg, 93%) as crystals.

Provenance & Evidence