1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → HCID 66751357, compound

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Reaction Steps

A mixture of 1-(2-tert-butylphenyl)piperazine dihydrochloride obtained in Reference Example 1 (1.0 g), 4-{[1-(tert-butoxycarbonyl)piperidin-4-yl]methoxy}benzoic acid obtained in Reference Example 6 (1.41 g), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (824 mg), 1-hydroxy-1H-benzotriazole monohydrate (659 mg), triethylamine (1.53 mL), and N,N-dimethylformamide (10 mL) was stirred at room temperature for over-night. Water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by flash column chromatography (NH-silica gel, 10:90-0:100 hexane/ethyl acetate) to provide the title compound (1.6 g, 87%) as crystals.

Provenance & Evidence