Ethyl isocyanate → HCID 66792705, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 1-(2-tert-butylphenyl)piperazine dihydrochloride (0.12 g, 0.41 mmol) in pyridine (4.0 mL) was added ethyl isocyanate (0.036 g, 0.51 mmol) at room temperature and the reaction mixture was heated at 50° C. for 16 h. After this time, the reaction mixture was cooled to room temperature and concentration under reduced pressure. The residue was partitioned between ethyl acetate and 0.5 N hydrochloric acid (2×10 mL), separated and the organic layer was concentrated under reduced pressure. The residue was purified by flash column chromatography (silica gel, 1:9 to 1:1 ethyl acetate/heptanes) to provide 4-(2-tert-butylphenyl)-N-ethylpiperazine-1-carboxamide (0.092 g, 77%) as a white solid, mp 196-198° C.

Provenance & Evidence