Phenyl isocyanate → HCID 66750951, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 1-(2-tert-butylphenyl)piperazine dihydrochloride (0.120 g, 0.41 mmol) in pyridine (4.0 mL) was added phenyl isocyanate (0.055 g, 0.46 mmol) and the reaction mixture was heated to 50° C. After 18 h the reaction mixture was concentrated under reduced pressure and the residue was purified by flash column chromatography (silica gel, 90:10 to 0:100 heptane/ethyl acetate, gradient elution) to provide 4-(2-tert-butylphenyl)-N-phenylpiperazine-1-carboxamide (0.093 g, 67%) as an off-white solid, mp 68-72° C.

Provenance & Evidence