Water → HCID 66792768, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred suspension of 1-(4-bromo-2-tert-butylphenyl)piperazine dihydrochloride (Reference Example 9, 0.300 g, 0.81 mmol) and triethylamine (564 μl, 4.05 mmol) in THF (10 mL) stirring at 0° C. was added ethyl chloro(oxo)acetate (0.144 mg, 1.05 mmol). The mixture was warmed to room temperature. After 16 h the reaction mixture was poured into water and extracted with ethyl acetate. The organic layer was washed with saturated sodium hydrogen carbonate and brine, dried over MgSO4, and the solvent was evaporated under reduced pressure to give the crude product. The product was purified by flash column chromatography (silica gel, n-hexane/ethyl acetate=80:20 to 50:50) to provide ethyl [4-(4-bromo-2-tert-butylphenyl)piperazin-1-yl](oxo)acetate (0.328 g, quant) as a white solid.

Provenance & Evidence