Triethylamine → HCID 66750881, compound

Participants

Reaction Steps

A suspension of 1-(4-bromo-2-tert-butylphenyl)piperazine dihydrochloride (Reference Example 9, 0.300 g, 0.81 mmol), 3-ethoxy-3-oxopropanoic acid (0.128 g, 0.97 mmol), EDCI (0.186 g, 0.972 mmol), HOBt (0.131 g, 0.972 mmol) and triethylamine (339 4.05 mmol) in acetonitrile (10 mL) was stirred at room temperature for 16 h. The reaction mixture was poured into saturated sodium hydrogen carbonate solution and extracted with ethyl acetate. The organic layer was washed with saturated sodium hydrogen carbonate solution and brine, dried over MgSO4, and the solvent was evaporated under reduced pressure to give the crude product. The product was purified by flash column chromatography (silica gel, n-hexane/ethyl acetate=80:20 to 50:50) to provide ethyl 3-[4-(4-bromo-2-tert-butylphenyl)piperazin-1-yl]-3-oxopropanoate (0.308 g, 93%) as a white solid.

Provenance & Evidence