Hydrochloric Acid → HCID 66750892, compound

Participants

Reaction Steps

To a stirred solution of methyl (4-{2-[4-(2-tert-butylphenyl)piperazin-1-yl]-2-oxoethyl}-2,6-dioxopiperidin-1-yl)acetate (Example 72, 0.463 g, 1.04 mmol) in THF (5 mL) stirring at 0° C. was added 1 M lithium hydroxide solution (5 mL, 5 mmol). After 3 h the reaction mixture was acidified with 1 M hydrochloric acid solution and extracted with ethyl acetate. The organic layer was washed with brine, dried over MgSO4, and the solvent was evaporated under reduced pressure to provide 5-[4-(2-tert-butylphenyl)piperazin-1-yl]-3-{2-[(carboxymethyl)amino]-2-oxoethyl}-5-oxopentanoic acid (0.505 g, quant) as a pale brown solid.

Provenance & Evidence