Hydrochloric Acid → HCID 49764240, compound

Participants

Reaction Steps

A mixture of ethyl [4-(2-tert-butyl-4-chlorophenyl)piperazin-1-yl](oxo)acetate (Example 179, 0.45 g, 1.28 mmol) and 1 M LiOH (3.8 mL) in EtOH (15 mL) was stirred at room temperature for 1 h. The reaction mixture was acidified with 1 M HCl, concentrated under reduced pressure, and partitioned between ethyl acetate and water. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The resulting white solid was triturated with diisopropyl ether to give the title compound (0.29 g) as a white solid: mp 154-155° C.

Provenance & Evidence