1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 66792801, compound

Participants

Reaction Steps

A mixture of 2-[4-(2-tert-butylphenyl)piperazin-1-yl]-2-oxoacetic acid (Example 44, 1.50 g, 5.12 mmol), tert-butyl 4-aminopiperidine-1-carboxylate (1.24 g, 6.2 mmol), EDCI (1.24 g, 6.2 mmol) and HOBt (0.95 g, 6.2 mmol) in N,N-dimethylformamide (20 mL) was stirred at room temperature for 16 h. The reaction mixture was added to saturated NaHCO3 solution and extracted with ethyl acetate. The extract was washed with saturated NaHCO3 solution, 1M HCl and brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the title compound (2.52 g, quant.) as a yellow amorphous.

Provenance & Evidence