Ethyl isocyanate → HCID 66792765, compound

Participants

Reaction Steps

A mixture of 2-[4-(2-tert-butylphenyl)piperazin-1-yl]-2-oxo-N-piperidin-4-ylacetamide dihydrochloride (0.35 g, 0.79 mmol), isocyanatoethane (72.5 mg, 1.02 mmol) and triethylamine (329 μL, 2.36 mmol) in tetrahydrofuran (10 mL) was stirred at room temperature for 16 h. The reaction mixture was poured into saturated NaHCO3 solution and extracted with ethyl acetate. The extract was washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the title compound (0.34 g, 99%) as a white solid.

Provenance & Evidence