Methanesulfonyl chloride → HCID 66751211, compound

Participants

Reaction Steps

A mixture of 2-[4-(2-tert-butylphenyl)piperazin-1-yl]-2-oxo-N-piperidin-4-ylacetamide dihydrochloride (Example 182(A), 0.30 g, 0.67 mmol) and methanesulfonyl chloride (0.10 g, 0.88 mmol) in pyridine (3 mL) was stirred at room temperature for 16 h. The reaction mixture was poured into saturated NaHCO3 solution and extracted with ethyl acetate. The extract was washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate 80:20 to 35:65) to give the title compound (0.13 g, 41%) as a white powder.

Provenance & Evidence