Hydrochloric Acid → HCID 66792755, compound

Participants

Reaction Steps

A mixture of methyl [4-({[4-(2-tert-butylphenyl)piperazin-1-yl](oxo)acetyl}amino)phenoxy]acetate (Example 200, 0.29 g, 0.64 mmol) and 1 M LiOH solution (5 mL, 5.0 mmol) in tetrahydrofuran (5 mL) was stirred at room temperature for 3 h. The reaction mixture was acidified with 1 M HCl solution and extracted with ethyl acetate. The extract was washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The residue was crystallized from diisopropyl ether to give the title compound (0.29 g, quant.) as a white solid.

Provenance & Evidence