Hydrochloric Acid → HCID 66792739, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl 3-[4-(2-tert-butyl-4-chlorophenyl)piperazin-1-yl]-3-oxopropanoate (Example 206, 0.35 g, 0.95 mmol) and 1 M LiOH solution (5 mL, 5.0 mmol) in tetrahydrofuran (5 mL) was stirred at 0° C. for 3 h. The reaction mixture was acidified with 1 M HCl solution and extracted with ethyl acetate. The extract was washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the title compound (0.32 g, 98%) as a white solid.

Provenance & Evidence