Trifluoroacetic acid → HCID 66792712, compound

Participants

Reaction Steps

A mixture of tert-butyl [(5-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}isoxazol-3-yl)oxy]acetate obtained in Example 215 (0.99 g, 2.23 mmol) and trifluoroacetic acid (8 mL) was stirred at room temperature for 3 h. The reaction mixture was neutralized with 1 M sodium hydroxide solution and the mixture was extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford a solid (0.74 g, 86%).

Provenance & Evidence