Triethylamine → HCID 66751357, compound

Participants

Reaction Steps

A mixture of 1-(2-tert-butylphenyl)piperazine dihydrochloride obtained in Reference Example 1 (1.0 g, 3.43 mmol), 4-{[1-(tert-butoxycarbonyl)piperidin-4-yl]methoxy}benzoic acid (1.41 g, 4.2 mmol), triethylamine (1.53 mL, 11.0 mmol), EDCI (0.824 g, 4.3 mmol) and HOBt (0.659 g, 4.3 mmol) in N,N-dimethylformamide (10 mL) was stirred at room temperature for 16 h. Water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to purify the residue by NH-silica gel column chromatography (hexane/ethyl acetate 10:90 to 0:100). Solvent was removed to obtain a solid (1.6 g, 87%).

Provenance & Evidence