Hydrogen chloride-ethyl acetate → HCID 66751341, compound

Participants

Reaction Steps

A mixture of tert-butyl 4-[(4-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}phenoxy)methyl]piperidine-1-carboxylate (1.5 g, 2.8 mmol) and 4 M hydrochloric acid-ethyl acetate solution (20 mL) in ethyl acetate (100 mL) and methanol (100 mL) was stirred at room temperature for 16 h. Solvent was removed in vacuo and 1 M sodium hydroxide solution was added to the mixture. The mixture was extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to obtain a solid (1.1 g, 90%).

Provenance & Evidence