HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 3-formylazetidine-1-carboxylate → 2-(Tert-butyl) 7-ethyl 2,6-diazaspiro[3.4]octane-2,7-dicarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 3-formylazetidine-1-carboxylate | HCID 10726182 | — |
| Reactant | 8-Tert-butyl 3-ethyl 2,8-diazaspiro[4.5]decane-3,8-dicarboxylate | HCID 49761235 | — |
| Product | 2-(Tert-butyl) 7-ethyl 2,6-diazaspiro[3.4]octane-2,7-dicarboxylate | HCID 58313058 | 93% |
Reaction Steps
This compound was prepared from 1,1-dimethylethyl 3-formyl-1-azetidinecarboxylate (650 mg, 3.5 mmol) in 93% yield in an analogous fashion to Intermediate 131 in Example 19.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08853416B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-252c8fe050ed4685a0129165922cc9fe |
| Source note | uspto-grants-2014_10 |