Hydrochloric Acid → HCID 68008293, compound

Participants

Reaction Steps

A 2-neck 250-mL round bottom flask was equipped with a condenser, a nitrogen inlet, and a magnetic stirrer. The flask was charged with 3-[9-(2-ethoxycarbonyl-ethyl)-2,7-dihexanoyl-9H-fluoren-9-yl]-propionic acid ethyl ester (10.76 g), 100 mL of water and 5.0 g of sodium hydroxide. The mixture was then heated to reflux overnight. The reaction mixture was cooled to ambient temperature and acidified to pH=1 by addition of 6N hydrochloric acid solution. The resulting solid was isolated by filtration and washed with three portions of water. The solid was dried under vacuum at 70° C. to give 8.5 g of the title compound. 1H NMR (CDCl3, 300 MHz) δ 8.02-7.98 (m, 4H), 7.82 (m, 2H), 2.99 (t, J=7.6 Hz, 4H), 2.47 (m, 4H), 1.74 (m, 4H), 1.53 (m, 4H), 1.40-1.34 (m, 8H), 0.91 (m, 6H).

Provenance & Evidence