反应详情

Using a procedure analogous to that described in Example 1a, the carboxamide was prepared from 12.8 g of 3-amino-2-chloro-4-methyl pyridine, 15.8 g of 2-chloronicotinoyl chloride, 7.1 g of pyridine, 30 ml of cyclohexane and 60 ml of dioxane. After removal of the solvent, the product was dissolved in methylene chloride, washed with water and dried (sodium sulfate). After removal of the solvent, the residue was washed with ethyl acetate to give 1.2 g of the title compound, m.p. 193°-194° C.

1. customAfter removal of the solvent
2. dissolutionthe product was dissolved in methylene chloride
3. washwashed with water
4. dry with materialdried (sodium sulfate)
5. customAfter removal of the solvent
6. washthe residue was washed with ethyl acetate