Hydrochloric Acid → 2-(4-Benzamido-2-oxopyrimidin-1(2H)-yl)acetic acid

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Reaction Steps

Compound 7 (1.38 g, 4.6 mmol) and NaOH (0.36 g, 9.2 mmol) were dissolved in water (10 mL) and the solution was stirred at room temperature for 2 h. Then the pH was adjusted to 3 using 1M HCl. The precipitate formed was separated by filtration, washed with 5 mL water and dried in vacuo to afford 3 as a white solid (1.16 g, 92%); ESI-MS m/z 274 [M+H]+; 1H NMR (400 MHz, D2O, sodium salt): δ7.78 (d, 1H, J=7.2 Hz), 7.75 (d, 2H, J=7.2H), 7.55 (t, 1H, J=7.2 Hz), 7.39 (t, 2H, J=7.2 Hz), 7.19 (d, 1H, J=7.2 Hz), 4.31 (s, 2H).

Provenance & Evidence