Isobutyryl chloride → HCID 135437285, compound

Participants

Reaction Conditions

Reaction Steps

Isobutyryl chloride (2.02 mL, 19.9 mmol) was added dropwise to a stirred suspension of guanine (3.02 g, 20 mmol) and TEA (1.45 mL, 10.4 mmol) in anhydrous pyridine (40 mL). The mixture was stirred for 3 h at 100° C. The reaction was quenched using methanol, and the solid was filtered, washed with methanol and dried in vacuo to give 10: yield 2.67 g (60%); MS (+ESI): m/z 222 [M+H]+.

Provenance & Evidence