Methyl 3-(4-hydroxyphenyl)hex-4-ynoate → HCID 58031836, compound

HRID 535272Notes

Reaction equation

HRID 535272 reaction equation
[Cl:1][C:2]1[CH:9]=[C:8]([O:10][CH2:11][C:12]2([CH2:15][OH:16])[CH2:14][CH2:13]2)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].O[C:18]1[CH:23]=[CH:22][C:21]([CH:24]([C:30]#[C:31][CH3:32])[CH2:25][C:26]([O:28]C)=[O:27])=[CH:20][CH:19]=1>>[Cl:1][C:2]1[CH:9]=[C:8]([CH:7]=[CH:6][C:3]=1[C:4]#[N:5])[O:10][CH2:11][C:12]1([CH2:15][O:16][C:18]2[CH:23]=[CH:22][C:21]([CH:24]([C:30]#[C:31][CH3:32])[CH2:25][C:26]([OH:28])=[O:27])=[CH:20][CH:19]=2)[CH2:13][CH2:14]1

Participants

3

Reactant 2

HCID 57835749Methyl 3-(4-hydroxyphenyl)hex-4-ynoateHCID 58031835HCID 58031835, compound

Product 1

HCID 58031836HCID 58031836, compound

Procedure

Analogously to example 1, 2-chloro-4-(1-hydroxymethylcyclopropylmethoxy)benzonitrile and methyl 3-(4-hydroxyphenyl)hex-4-ynoate were used to obtain 3-{4-[1-(3-chloro-4-cyanophenoxymethyl)cyclopropylmethoxy]phenyl}hex-4-ynoic acid.

Sources & evidence

ORD record
ord-3ab5f21c9ef54bcbb06013a216365a6d
Source dataset
uspto-grants-2014_10
Patent number
US08859494B2

Reaction notes

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