HCID 58031832, compound → HCID 66628558, compound

HRID 535275Notes

Reaction equation

HRID 535275 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]([O:22][CH3:23])[CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:11][CH:10]=1)C1C=CC=CC=1>C(O)C.[Pd]>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([CH:15]([O:22][CH3:23])[CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:13][CH:14]=1

Participants

4

Reactant 1

HCID 58031832HCID 58031832, compound

Product 1

HCID 66628558HCID 66628558, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

9.3 g of ethyl 3-(4-benzyloxyphenyl)-3-methoxypropionate were dissolved in 200 ml of ethanol, and 1.1 g of palladium on activated carbon (10%) were added. The mixture was stirred under a hydrogen atmosphere at room temperature for two hours. The reaction mixture was filtered through a nylon membrane filter (0.45 μm) and washed with 200 ml of ethanol, and the filtrate was concentrated under reduced pressure. This gave 6.7 g of ethyl 3-(4-hydroxyphenyl)-3-methoxypropionate.

Workup

  1. filtrationThe reaction mixture was filtered through a nylon membrane
  2. filtrationfilter (0.45 μm)
  3. washwashed with 200 ml of ethanol
  4. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-cb8461d4a2494f92b8d7be76e50aca43
Source dataset
uspto-grants-2014_10
Patent number
US08859494B2

Reaction notes

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