反应详情

Sodium methoxide (26.1 g) was added to a solution of 2-chloro-4-methyl-5-nitropyridine (19.0 g) in methanol (100 ml) and the resulting mixture was refluxed for 12 hours. Upon cooling, the mixture was poured over water (1 L), and the product was extracted with ethyl acetate and washed with water. The organic phase was dried (anhydrous magnesium sulfate) and concentrated, and the residue dissolved in hot ether and filtered. Crystallization from ether provided 10.2 g of the title compound, suitable for use in the next reaction.

1. temperaturethe resulting mixture was refluxed for 12 hours
2. temperatureUpon cooling
3. extractionthe product was extracted with ethyl acetate
4. washwashed with water
5. dry with materialThe organic phase was dried (anhydrous magnesium sulfate)
6. concentrationconcentrated
7. dissolutionthe residue dissolved in hot ether
8. filtrationfiltered
9. customCrystallization from ether