HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → HCID 87253071, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-(2,5-Dioxopyrrolidin-1-yl)-1,1,3,3-tetramethylisouronium tetrafluoroborate | HCID 9857522 | — |
| Reactant | HCID 72302912 | HCID 72302912 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 87253071 | HCID 87253071 | — |
Reaction Steps
2-[3-(3-{4-[3-(7-tert-butoxycarbonylheptanoylamino)propoxy]butoxy}-propylcarbamoyl)-propionylamino]pentanedioic acid 1-tert-butyl ester (1.5 g, 2.14 mmol) was dissolved in THF (20 mL), pH was adjusted to 8.5 with DIPEA (0.9 mL), TSTU (0.83 g, 2.77 mmol) was added in DMF (5 mL). The mixture was stirred under nitrogen overnight, subsequent evaporation and extraction between EtAc and HCl as described above resulted in 1.75 g crude product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08859493B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-5f248fcecc4541ddbf95087efae37e63 |
| Source note | uspto-grants-2014_10 |