N-{2-[2-(2-tert-butoxycarbonylamino-ethoxy)-ethoxy]-ethyl}-succinamic acid → 9-(2-{2-[2-(3-Carboxypropionylamino)ethoxy]ethoxy}ethylcarbamoyl)nonanoic acid tert-butyl ester
Reaction equation
O=C1CCC(=O)N1O[C:9](=[O:25])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19].C(OC([NH:33][CH2:34][CH2:35][O:36][CH2:37][CH2:38][O:39][CH2:40][CH2:41][NH:42][C:43](=[O:49])[CH2:44][CH2:45][C:46]([OH:48])=[O:47])=O)(C)(C)C>>[C:21]([O:20][C:18](=[O:19])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][C:9](=[O:25])[NH:33][CH2:34][CH2:35][O:36][CH2:37][CH2:38][O:39][CH2:40][CH2:41][NH:42][C:43](=[O:49])[CH2:44][CH2:45][C:46]([OH:48])=[O:47])([CH3:22])([CH3:23])[CH3:24]Participants
3
Procedure
Preparation from decanedioic acid tert-butyl ester 2,5-dioxo-pyrrolidin-1-yl ester (1.13 g, 3.45 mmol) and N-{2-[2-(2-tert-butoxycarbonylamino-ethoxy)-ethoxy]-ethyl}-succinamic acid (1 g, 2.84 mmol) as described in step 3 example 8 gave 1.68 g crude product which was used without further purification. LCMS (Method 6): Rt 3.86 min; m/z (M+1) 489; Calcd.: 489.
Sources & evidence
- ORD record
- ord-c2037a93311c4213a9f4908a809bbb24
- Source dataset
- uspto-grants-2014_10
- Patent number
- US08859493B2
Reaction notes
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