2-(2,5-Dioxopyrrolidin-1-yl)-1,1,3,3-tetramethylisouronium tetrafluoroborate → HCID 87253064, compound

HRID 535289Notes

Reaction equation

HRID 535289 reaction equation
C([O:5][C:6](=[O:45])[C@@H:7]([NH:13][C:14](=[O:44])[CH2:15][CH2:16][C:17](=[O:43])[NH:18][CH2:19][CH2:20][O:21][CH2:22][CH2:23][O:24][CH2:25][CH2:26][NH:27][C:28](=[O:42])[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][C:35]([O:37][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:36])[CH2:8][CH2:9][C:10]([OH:12])=[O:11])(C)(C)C.[B-](F)(F)(F)F.CN(C(O[N:59]1[C:64](=[O:65])[CH2:63][CH2:62][C:60]1=[O:61])=[N+](C)C)C>>[O:61]=[C:60]1[CH2:62][CH2:63][C:64](=[O:65])[N:59]1[O:5][C:6](=[O:45])[C@@H:7]([NH:13][C:14](=[O:44])[CH2:15][CH2:16][C:17](=[O:43])[NH:18][CH2:19][CH2:20][O:21][CH2:22][CH2:23][O:24][CH2:25][CH2:26][NH:27][C:28](=[O:42])[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][C:35]([O:37][C:38]([CH3:39])([CH3:40])[CH3:41])=[O:36])[CH2:8][CH2:9][C:10]([O:12][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:11]

Participants

3

Reactant 2

HCID 98575222-(2,5-Dioxopyrrolidin-1-yl)-1,1,3,3-tetramethylisouronium tetrafluoroborateHCID 59476994HCID 59476994, compound

Product 1

HCID 87253064HCID 87253064, compound

Procedure

(S)-2-[3-(2-{2-[2-(7-tert-Butoxycarbonylheptanoylamino)ethoxy]ethoxy}-ethylcarbamoyl)propionylamino]pentanedioic acid 1-tert-butyl ester (0.6 g, 0.93 mmol) was activated with TSTU using the procedure described above.

Sources & evidence

ORD record
ord-f18554330b854a528c5b38f33e2d3216
Source dataset
uspto-grants-2014_10
Patent number
US08859493B2

Reaction notes

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