Trifluoroacetic acid → HCID 71145730, compound

Participants

Reaction Steps

Example 56 was obtained from example 55. A solution of 3-{4-[(S)-1-(4-Chloro-phenyl)-7-isopropoxy-6-methoxy-3-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-phenyl}-3-hydroxy-azetidine-1-carboxylic acid tert-butyl ester (70 mg, 0.118 mmol) in DCM (1 ml) was immersed in an ice-bath followed by addition of TFA (0.045 ml, 0.590 mmol). The yellow reaction solution turned brown and was stirred for 30 minutes. The reaction mixture was treated with ice/saturated aq. sodium hydrogencarbonate solution and extracted with DCM. The organic phase was separated, dried over sodium sulfate, filtered and concentrated in vacuo to obtain the title compound as yellowish solid.

Provenance & Evidence