HCID 71145171, compound → HCID 71145601, compound

Participants

Reaction Steps

To a solution of (4-Bromo-phenyl)-(2-oxa-bicyclo[2.2.2]oct-4-yl)methanol (224 mg, 0.821 mmol) in DCM (13 ml) was added a total of manganese dioxide (1.414 g, 16.264 mmol) at RT and the reaction mixture was stirred for 20 hrs. The suspension was filtered through a pad of hyflo and the residue was washed with DCM, dried in vacuo to yield the title intermediate (220 mg, 0.745 mmol, 91%) as a colourless solid.

Provenance & Evidence