HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → 5-Bromo-4-chloro-6-(2-phenylethynyl)pyridin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 4-Chloro-6-(2-phenylethynyl)pyridin-2-amine | HCID 86694368 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 5-Bromo-4-chloro-6-(2-phenylethynyl)pyridin-2-amine | HCID 86694373 | — |
Reaction Steps
A mixture of 4-chloro-6-(2-phenylethynyl)pyridin-2-amine B3a (1.0 g, 4.37 mmol), NBS (778 mg, 4.37 mmol) and ACN (20 ml) is stirred for 3 h at RT in the dark. The mixture is concentrated in vacuo and the product purified NP chromatography. Yield: 1.0 g (74%). HPLC-MS: M+H=307/309.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08859541B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-353c3fa3196042598fd525898b4361c0 |
| Source note | uspto-grants-2014_10 |